Respiratory InSITE

State of the Art Respiratory Pathogen Detection

The Absolute Genomics Respiratory InSITE pathogen panel is designed for the detection of key respiratory tract microbial targets. The test is optimized for detection of respiratory tract viral and bacterial nucleic acid. The OpenArray technology allows for the detection of multiple pathogens in a single multiplex PCR reaction within a short span of 2-3 hours. The ability to detect polyinfections helps physicians to make important treatment decisions in a timely manner. The antibiotic resistance stewardship reduces the need for unnecessary antibiotic use, which contributes the reduction of treatment costs and hospital stays. The Absolute Genomics Respiratory InSITE panel is vital for high-risk populations like immunocompromised patients, children, and people above 70 years of age. With timely diagnosis, this test can help in early treatment and reducing mortality rates associated with respiratory illnesses in high-risk populations

Clinical Need :

  • Respiratory infections are easily transmissible via breathing, sneezing, and coughing
  • Respiratory illness can include Bronchitis, the common cold, and lower respiratory tract infections
  • The United States has higher cases of Influenza, Rhinovirus, and RSV than other parts of the world
  • High-risk populations for respiratory infections include children, the elderly, immunocompromised individuals, people living in congregate settings or sharing close spaces such as schools, hospitals, nursing homes, prisons, shelters, and more.
  • According to the CDC, the rate of respiratory illness is increasing in the U.S. population over the last decade
  • There are more than 40 million cases of respiratory infections each year
  • Approximately 1 million people are hospitalized each year resulting in a ~1% mortality rate
  • The situation in USA has worsened in the last two years with SARSCoV-2 (COVID-19) infections

Influenza leads to respiratory tract infections in 5-15% of the people annually

~40 million respiratory infections annually

40 million
Influenza leads to respiratory tract infections in 5-15% of the people annually
Influenza leads to respiratory tract infections in 5-15% of the people annually
~40 million respiratory infections annually
~40 million respiratory infections annually

ABx Advantage

The Absolute Genomics ABx Advantage gene panel is designed to detect major classes of antibiotic resistance. This panel can identify the presence of specific resistance genes that are involved in drug inhibition. The Absolute Genomics ABx Advantage gene panel has 11 antibiotic resistance genes belonging to amino glycosidea β-lactama fluoroquinolonea macrolidea tetracyclinea vancomycina and multi-drug resistance classifications. The data is used for providing antibiotic resistance stewardship via Arkstone Medical Solutions. The OneChoice report powered by Arkstone Medical Solutions for the ABx Advantage gene panel converts PCR data into simple interpretations for physicians to help them make better treatment decisions. This technology is a combination of softwarea artificial intelligencea and human expertise.

  • The antimicrobial report contains a unique ArkScore to help prescribers make informed decisions.
  • The antimicrobial decision engine combines machine-learning artificial intelligence with decades of deep infectious disease expertise to guide physicians to a singular treatment regimen that targets the most relevant infection with the lowest risk to the patient.
  • ArkScore describes the level of antimicrobial resistance expressed in organisms.
  • ArkScore provides the most effective treatment with the least risk of adverse events resulting in the reduction of unnecessary use of broad-spectrum antibiotics

Extensive Panel List

Bacteria Bordetella pertussis Chlamydia pneumoniae Haemophilus influenzae Klebsiella pneumoniae Legionella pneumophila Mycoplasma pneumoniae Staphylococcus aureus Streptococcus pneumoniae

Bacteria

  • Bordetella pertussis
  • Chlamydia pneumoniae
  • Haemophilus influenzae
  • Klebsiella pneumoniae
  • Legionella pneumophila
  • Mycoplasma pneumoniae
  • Staphylococcus aureus
  • Streptococcus pneumoniae
Viruses Adenovirus Coronavirus 229E Coronavirus HKU1 Coronavirus NL63 Coronavirus OC43 Enterovirus D68 Human Metapneumovirus Influenza A Influenza A H1 Influenza A H3 Influenza B Parainfluenza 1 Parainfluenza 2 Parainfluenza 3 Parainfluenza 4 RSVA RSVB Rhinovirus

Viruses

  • Adenovirus
  • Coronavirus 229E
  • Coronavirus HKU1
  • Coronavirus NL63
  • Coronavirus OC43
  • Enterovirus D68
  • Human Metapneumovirus
  • Influenza A
  • Influenza A H1
  • Influenza A H3
  • Influenza B
  • Parainfluenza 1
  • Parainfluenza 2
  • Parainfluenza 3
  • Parainfluenza 4
  • RSVA
  • RSVB
  • Rhinovirus
Respiratory InSITE Antibiotic Resistance Genes Bla-SHV FOX IMP-1 Mcr-1 MecA MeCC NDM-1 (C) TetS VanA VanB VIM

Respiratory InSITE Antibiotic Resistance Genes

  • Bla-SHV
  • FOX
  • IMP-1
  • Mcr-1
  • MecA
  • MeCC
  • NDM-1 (C)
  • TetS
  • VanA
  • VanB
  • VIM